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[1] This abnormal keratinization and skin cell proliferation combined with down-regulating 5α-Reductase (due to insufficient IGF-1) [19] eventually atrophies the sebaceous glands by reducing sebocyte proliferation that would typically be induced by DHT, if not for the loss of 5α-Reductase regulation from IGF-1

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Thus, tissue-specific promoters, such as the endosperm-specific α -kafirin and β -kafirin promoters, or the developmentally regulated Sh2 promoter, are increasingly valuable (Liu et al., 2020)